Eosinophilia and elevated immunoglobulin E (IgE) levels are laboratory markers commonly associated with different clinical conditions, including allergic disorders, parasitic infections, and certain hematological malignancies. IgE level is an immunological marker that reflects the activation of the immune system in response to a specific stimulus, often associated with type 2 hypersensitivity reactions, where IgE antibodies mediate the immune response to allergens [1]. The gene discussed is IGHE; the disease is hematologic disorder.