IGHE and Chronic Eosinophilic Leukemia, Not Otherwise Specified: Furthermore, eosinophilia and elevated IgE levels may also be seen in less frequent and more complex conditions, such as autoimmune diseases, malignancies (e.g., eosinophilic leukemia or lymphoma), or vasculitis. Although these findings are typically linked to well-established pathophysiological mechanisms, their occurrence in isolated or unusual clinical presentations warrants detailed investigation [2].