When eosinophilia and elevated IgE are both present, it is crucial to consider conditions involving dysregulated immune responses, such as allergic reactions, hyper-IgE syndrome, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), or other systemic inflammatory disorders. This evidence concerns the gene IGHE and eosinophilic granulomatosis with polyangiitis.