She had no physical complaints and the physical examination was unremarkable, with no evidence of hepatosplenomegaly or lymphadenopathy. The patient denied potential causes of eosinophilia and elevated IgE levels, including common allergies (e.g., allergic rhinitis, asthma, atopic dermatitis), symptoms compatible with parasitic infections, or constitutional symptoms that could be suspicious of hematological conditions (e.g., eosinophilic leukemia, lymphoma). The gene discussed is IGHE; the disease is Chronic Eosinophilic Leukemia, Not Otherwise Specified.