AKT1 and primary biliary cholangitis: Gene ontology enrichment analysis identified expected biological processes such as extracellular matrix organization and the collagen metabolic process while KEGG pathway analyses revealed cellular processes such as ECM-receptor interaction and pathways linked with cancer such as PI3K-AKT signaling pathway as displayed in Fig. 2C and D. Similarly, we categorized the samples of patients with PBC or MASLD into early and advanced fibrosis and analyzed them separately.