SFRP4 and Hepatic fibrosis: Although cell type-specific assignment was not possible for several genes, some of them had already been attributed to non-PSC liver fibrosis such as CTHRC128 or to non-liver fibrosis such as SFRP4. 29,30 We also found TMEM178B, which has recently been discovered as being upregulated in biliary fibrosis in people with biliary atresia.31