Of those, 39 showed fibroblast specificity, as displayed in Fig. 3B, amongst them well characterized genes mostly coding for extracellular matrix (ECM) proteins (e.g. COL1A1, COL1A2, FBLN1, LUM) or genes being previously associated to non-PSC liver fibrosis such as AEBP1,18MFAP4,19,20 and NFATC4. 21. The gene discussed is COL1A1; the disease is Hepatic fibrosis.