ESR1 and breast cancer: Our data showed that double knocked-down of ER and SHP2 and single knocked-down of SHP2 did not show significantly different effects on the P4-increased T47D proliferation (Supplementary Figure 1) and migration (Supplementary Figure 2), suggesting that the requirement of SHP2 in the P4-promoted breast cancer cell proliferation and migration was not specific to ER+, PR+ breast cancer cells.