After adjusting for age, sex, BMI, log NT-proBNP, LVEF, hemoglobin, renal function, coronary heart disease and hypertension, the AT VO2 was lower in T2DM group than in the non-T2DM group, with a mean difference (95% CI) of −1.11 (−2.04 to −0.18) ml/kg/min (P < 0.05). This evidence concerns the gene NPPB and type 2 diabetes mellitus.