CD274 and hepatocellular carcinoma: qRT-PCR results revealed that knocking down ENTPD8 reduces PD-L1 levels in HCC cells (Figures 7A, 7B, S3A, and S3C), whereas overexpressing ENTPD8 increases PD-L1 levels (Figures 7C, 7D, S3B, and S3D).