SLC7A11 and lung cancer: AIFM2,65 SLC7A11,66 and AKR1C family67 are all regulated by NRF2, a transcription factor with overactivation in STK11mut/KEAP1mut lung cancer cells, which explains the high mRNA levels of these genes in NCI-H1944 that harbors STK11 and KEAP1 mutations (Figures 6I and S12A).