Overlapping pathways between the two monocyte populations for the comparison of interest included communication between innate and adaptive immune cells, hematopoiesis from pluripotent stem cells, CCR5 signaling in macrophages, IL15 signaling and multiple other pathways with known roles in osteoarthritis and rheumatoid arthritis (Table S2). This evidence concerns the gene CCR5 and rheumatoid arthritis.