The higher-grade gliomas of pediatric type can be further divided into four subtypes: diffuse midline glioma, H3 K27 altered; diffuse hemispheric glioma, H3 G34 mutant; diffuse pediatric-type high-grade glioma, H3 wildtype; and IDH wildtype; infant-type hemispheric glioma (2). Here, IDH1 is linked to central nervous system cancer.