CEACAM5 and neoplasm: In the logistics multivariate analysis, with pathological complete response as the favorable outcome and all the pre-surgery clinical factors as the researching factors, the CEA trajectory subtypes and tumor differentiation are the only two independent factors that are associated with pCR, as shown in the Figure 4, the CEA trajectory subtypes have a significant higher weights in the model, indicating that CEA trajectory subtypes have more predictive power.