MGMT and glioblastoma: It has also been shown that TMZ has radiosensitizing effects [31–32], increasing the degradation of DNA strains and cell death when combined with RT, which is a reason for the National Comprehensive Cancer Network to recommend standard RT and adjuvant TMZ plus alternating electric field therapy for patients with GBM at ages up to 70 years with good performance status and having either a “methylated” or “indeterminate” MGMT promoter status [33].