The role of KLF4 in anti-tumor immunity is crucial and deserves special attention as studies have shown that, in hepatocellular carcinoma (HCC), KLF4 is significantly associated with CD8+ T cells, Th1 cells, dendritic cells (DCs), B cells, natural killer (NK) cells, macrophages, and their molecular markers (138). This evidence concerns the gene KLF4 and hepatocellular carcinoma.