KLF4 and gastric cancer: For instance, in cancers such as urothelial carcinoma, renal cell carcinoma, medulloblastoma, colorectal adenocarcinoma, and gastric cancer, KLF4 is often silenced due to promoter hypermethylation, which recruits DNA-binding proteins or histone deacetylases (HDACs), leading to chromatin compaction and transcriptional repression (93–97).