CSF3 and esophageal squamous cell carcinoma: demonstrated that KLF4 overexpression in mouse esophageal epithelial cells activates pro-inflammatory factors such as TNF-α, CXCL5, Granulocyte Colony-Stimulating Factor(G-CSF), and IL-1α, a process that also relies on NF-κB, ultimately leading to the development of esophageal squamous cell carcinoma (161).