This approach has revealed a potential transcriptome signature in PECs that connects purinergic receptors with transcriptome signatures strongly associated with lupus such as the transcriptome signature of type I interferon-regulated genes, the cyclic GMP-AMP synthase-stimulator of interferon genes the cGAS-STING signaling pathway, and the NLRP3 inflammasome. Here, P2RY2 is linked to systemic lupus erythematosus.