STING mediates lupus via the activation of conventional dendritic cell maturation and plasmacytoid dendritic cell differentiation in the Fcgr2b-deficient lupus mice (118), and increased cGAS expression and cGAMP in a proportion of SLE patients indicated that the cGAS/cGAMP pathway may play a role in disease expression (119). The gene discussed is CGAS; the disease is systemic lupus erythematosus.