Some miRNAs (miR-1246/92b-3p/27a-3p) enriched in Fn-Exs can directly suppress glycogen synthase kinase-3β (GSK3β) expression and activate Wnt/β-catenin pathway (37), thereby promoting CRC cell migration, and ultimately contributing to tumor metastasis. Here, GSK3B is linked to colorectal carcinoma.