Since there is limited research on the role of IL-1α in liver fibrosis, this review primarily focuses on IL-1β, an inducible and highly inflammatory cytokine.IL-1β activates a complex signaling cascade via IL-1R1, which subsequently triggers transcription factors such as nuclear factor-kappa B (NF-κB) and induces the production of inflammatory cytokines (12). Here, NFKB1 is linked to Hepatic fibrosis.