In patients with chronic liver disease, serum expression of IL-1β is elevated, and IL-1β has been shown implicated of hepatic steatosis to steatohepatitis and hepatic fibrosis (16, 17).Hepatic tissue expression of IL-1α and IL-β is significantly increased in diet-induced nonalcoholic steatohepatitis (NASH) models, indicating that these cytokines are involved in the regulation of steatosis and steatohepatitis. Here, IL1A is linked to metabolic dysfunction-associated steatohepatitis.