In vivo and in vivo studies revealed that Aspergillus extracts ameliorated carbon tetrachloride (CCl4)-induced liver fibrosis and TGF-β-induced HSCs activation, likely through the Nrf2-mediated inhibition of the Reactive Oxygen Species/NOD-like Receptor Pyrin domain-containing 3/Interleukin-1 alpha (ROS/NLRP3/IL-1β) signaling pathway (32). This evidence concerns the gene NLRP3 and Hepatic fibrosis.