A recent study found that, in a mouse model of CCl4-induced liver fibrosis, the Citrus aurantium extract astragalin inhibited the expression of TNF-α, IL-18, and IL-1β mRNAs in the livers of fibrotic mice through the NF-κB/NLRP3 inflammasome pathway, significantly ameliorating liver fibrosis (69). The gene discussed is IL18; the disease is Hepatic fibrosis.