CD8A and non-small cell lung carcinoma: In particular, in these NSCLC patients, arginase-1 (ARG1)-expressing neutrophils negatively correlates with the proportion of CD8+ T cells, while ARG1-expressing granulocytic cells can lead to CD3ζ chain downregulation on T cells though L-arginine depletion and ultimately inhibit T-cell proliferation and cytokine secretion.