NEFL and early-onset autosomal dominant Alzheimer disease: Previous cross-sectional studies have likewise demonstrated a negative correlation between plasma NfL and verbal episodic memory performance among individuals with subjective cognitive decline or with pathological levels of Alzheimer’s disease biomarkers.18,62 Similarly, another study reported a negative relationship between plasma NfL levels and a composite episodic memory score among cognitively normal and MCI older adults.16 Collectively, these studies support the utility of plasma NfL as a correlate of episodic memory performance, which is consistent with our results.