MKI67 and neoplasm: Finally, to clarify the therapeutic mechanism of NOSH@PEG-HCuSNPs, we performed histological analysis, and further performed H&E, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) staining, and Ki67 antibody staining to observe the inhibitory effect of the treatment on tumor cells and further evaluate the efficacy of each treatment.