In addition, granzyme B (GZMS-B) [53], which plays a role in killing tumor cells in CTLs, and prostaglandin E2 (PGE2) [54], which helps tumor cells escape the immune system, were significantly increased and decreased in the blood supernatant of mice after NOSH@PEG-HCuSNPs-mediated combined treatment, respectively. This evidence concerns the gene GZMB and neoplasm.