While there are reports suggesting that variability in the COMT SNP rs4680 c.472 G>A is accountable for different outcomes of pain sensitivity,13,20 there are others suggesting that the prediction of pain sensitivity is based on COMT haplotypes, which were shown to be associated with different sensitivities for experimental pain.4,5 According to Diatchenko et al.,5 there are 3 polymorphisms within the COMT gene (rs6269, rs4633, rs4814) that form a haploblock with rs4680, which underlie the LPS/APS/HPS haplotypes. The gene discussed is COMT; the disease is autoimmune polyendocrinopathy.