TRAF6 and cancer: According to a previous study, lactate-induced histone acetylation inhibited RARγ expression in macrophages and activated the TRAF6-IL-6-STAT3 signaling axis, which drove the synthesis of the pro-inflammatory factor IL-6 by tumor-associated macrophages (TAMs) and enhanced the proliferative and migratory abilities of cancer cells through STAT3 signaling (Li X.-M.