Moreover, Sch B induces cell cycle arrest of glioma cells in the G0/G1 phase, triggers apoptosis through the activation of caspase-3, caspase-9, poly (ADP-ribose) polymerase (PARP), and Bcl-2, and significantly inhibits the tumor growth of glioma cells in vivo (Li et al., 2015; Qi et al., 2016). Here, CASP3 is linked to central nervous system cancer.