Sch B can also restrain the phosphorylation and nuclear translocation of signal transducer and activator of transcription 3 (STAT3), induce cell cycle arrest and apoptosis, thereby inhibiting the growth, migration and clone formation of TNBC cell cells and exerting its anti-breast cancer effect through preclinical studies (Dai et al., 2018). The gene discussed is STAT3; the disease is breast carcinoma.