Sch B exerts its effect on the PI3K/Akt signaling pathway by modulating the circ_0009112/miR-708-5p axis, promoting the apoptosis of osteosarcoma cells and significantly suppressing the growth and lung metastasis of osteosarcoma in animal models (Wang et al., 2020; Wang et al., 2022). This evidence concerns the gene AKT1 and osteosarcoma.