SOD1 and amyotrophic lateral sclerosis: In a parallel study utilizing the identical rodent model of ALS, Jiang et al. corroborated these observations and demonstrated that guanabenz markedly postponed the advent of disease symptoms, extended survival, augmented motor performance, decelerated body weight loss, and prolonged motor neuron survival in the lumbar spinal cord of female SOD1 G93A mice [163].