PRPH expression has been demonstrated also in pancreatic islet beta‐cells (Boitard et al. 1992) and interestingly, autoreactive B cells characterized by a specific immune response to peripherin have been demonstrated to have a significant role in the non‐obese diabetic mouse model, representing a heterogeneous population proliferating as diabetes develops (Song et al. 2009). This evidence concerns the gene PRPH and diabetes mellitus.