ChIP‐Seq and ChIP‐qPCR analysis allowed us to identify a subset of hypoxia‐regulated genes that are co‐occupied by both TFAP2A and HIF‐1α, both in HeLa and MCF7 cancer cell lines, providing evidence that binding of TFAP2A to HIF‐inducible promoters is not a cell type‐specific event. Here, HIF1A is linked to cancer.