To understand if peripheral immune cells in the CNS also show a decrease in RGS10 and may therefore impact the induction of neuroinflammation, we investigated the protein level of RGS10 in the CSF of healthy controls, prodromal individuals with increased risk of developing PD, and individuals with diagnosed PD in the Michael J. Fox Foundation for Parkinson’s Research Parkinson’s Progression Markers Initiative (PPMI) study. This evidence concerns the gene RGS10 and Parkinson disease.