Furthermore, after infection and the addition of a PKA activator, the expression levels of p-CREB (P < 0.05), C/EBPβ (P < 0.05), Arg-1 (P < 0.01), and IL-10 (P < 0.05) were significantly upregulated in human dMφ compared with those of the group infected with T. gondii alone (Fig. 6b). This evidence concerns the gene CREB1 and infection.