We injected WP1066 (a STAT3 inhibitor) intraperitoneally into knockdown CPEB3 mice and examined the protein and mRNA expression of GluN1, GluN2A, and GluN2B to verify whether CPEB3 inhibits the transcriptional activity of NMDARs via STAT3 in epilepsy. This evidence concerns the gene GRIN1 and epilepsy.