Activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is observed in several central nervous system disorders, including epilepsy (Han et al. 2020; He et al. 2020; Hristova et al. 2016; Li et al. 2021; Toral-Rios et al. 2020). Here, SOAT1 is linked to epilepsy.