FTO and aortic valve stenosis: We observed an association between elevated regional autozygosity and increased levels of urinary ACR at a specific region on chromosome 2 encompassing FTO and CRNDE. FTO is a protein-coding gene, and the variant within this gene is strongly associated with the pathogenesis of various diseases and disorders, including obesity, hypertension, and cardiovascular disorders such as heart failure, acute coronary syndrome, and aortic valve stenosis.