In addition, the UPR has been implicated in a number of model systems for cataract, including selenite cataracts in rat lenses24 sugar cataracts in galactosemic rat lenses25 and transgenic expression of abnormal collagen IV26 mutant connexin 5027 and αA- and αB-crystallins28 in transgenic mice. Here, TEAD1 is linked to cataract.