EIF2AK3 and cataract: This involves activation of the PERK (EIF2AK3)) endoplasmic reticulum UPR pathway and the ATF4 mitochondrial UPR pathway, with the age of onset and severity of the cataracts as well as induction of the UPR, autophagy, and apoptosis being dependent on the levels of CRYGC5bpdup mRNA expressed in the mouse lens.