MGMT and central nervous system cancer: SMARCAL1 demonstrated moderate accuracy in predicting Glioma (AUC = 0.729), LUAD (AUC = 0.784), LIHC (AUC = 0.864), KIRC (AUC = 0.625), and UCEC (AUC = 0.673), as illustrated in Fig. 2B. The Cox regression analysis revealed that SMARCAL1 expression was a predictive factor for Glioma that was independent of known prognostic markers such as WHO grade, age at diagnosis, IDH mutation, 1p/19q codeletion, and MGMT promoter methylation.