In this study, we used a number of bioinformatics techniques to investigate the possible oncogenic or tumor-suppressive function of SMARCAL1, by assessing the relationship between the expression levels of SMARCAL1 and the following parameters in human pan-cancer cells: overall survival (OS), DNA methylation, tumor mutational burden (TMB), immune infiltration, and classical immune checkpoint genes. This evidence concerns the gene SMARCAL1 and neoplasm.