SOX2 and cancer: SOX2 is a critical factor in preserving stemness and has been implicated in sustaining the undifferentiated tumorigenic state across various cancers.39 Several studies have demonstrated that this stem cell transcription factor is essential for maintaining cancer stem cells (CSCs) in sarcomas.13,24,40 Importantly, our immunohistochemical results showed higher expression of SOX2 and p-AKT in tumor samples from chemotherapy-resistant patients compared to chemotherapy-sensitive patients.