For example, Su et al. developed a carbonic anhydrase IX (CAIX)-anchored rhenium(I) photosensitizer (CA-Re) and found that it not only enabled type I and type II photodynamic therapy (PDT) under hypoxic conditions but also triggered GSDMD-mediated pyroptosis to enhance tumor immunogenicity [219]. The gene discussed is GSDMD; the disease is neoplasm.