Neurological diseases can be broadly categorized into cerebrovascular diseases [26, 27, 68, 69], and neurodegenerative diseases [53, 62, 67], which are closely associated with the AIM2-caspase-1-GSDMD and NLRP3-caspase-1-GSDMD inflammasome signaling pathways. This evidence concerns the gene CASP1 and neurodegenerative disease.