Beneforti et al. discovered that the pro-inflammatory cytokines, such as IL-1β, tumor necrosis factor-α (TNF-α), and IL-6 which are released in response to different sorts of infections [16], work with BM-MSCs to help ETV6-RUNX1-expressing cells find a suitable niche and become more susceptible to transformation through elevated DNA damage [17]. This evidence concerns the gene TNF and infection.