The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis demonstrated that the enriched pathways were T‐cell receptor, RIG‐1 like receptor, chemokine and JAK/STAT signalling for ESCC (Figure S3A) and chemokine, T‐cell receptor and B‐cell receptor signalling for EAC (Figure S3B). This evidence concerns the gene SOAT1 and esophageal squamous cell carcinoma.