Meanwhile, IRF5 was highly expressed in malignant regions in the expression difference between colon cancer (Figure 1D (P1‐3)) and gastric cancer (P4); interestingly, in patients with liver metastases from colon cancer (Figure S1D), we found that IRF5 was lowly expressed in malignant regions and highly expressed in mixed malignant regions, which may be related to the presence of spatial variability. Here, IRF5 is linked to colonic neoplasm.