Recent studies have found that PUE can induce adaptive autophagy and protect the heart from LPS‐induced injury by activating the 14‐3‐3γ/PKCε pathway [12], whereas another study reported that PUE protects cardiomyocytes from ischemia–reperfusion injury by inhibiting autophagy through the Akt signalling pathway [29], inhibiting collagen secretion and reducing myocardial fibrosis [30]. This evidence concerns the gene AKT1 and Myocardial fibrosis.