Moreover, hsa_circ_0045932, circ‐CCS and circ‐PITHD1 were shown to function as sponges of miR‐873‐5p, miR‐874‐3p and miR‐590‐5p, respectively, increasing HK2 expression and enhancing CRC cell growth, invasion, dispersion and drug resisitance [103, 104, 105]. This evidence concerns the gene HK2 and colorectal carcinoma.