BRCA1 and breast cancer: The differential role of BRCA1 and BRCA2 PVs in the age-related risk of developing breast cancer and other malignancies is well established,27 with subsequent distinct recommendations for surveillance and prevention strategies.5 Moreover, age <40 years at primary diagnosis is a known risk factor for cumulative risk of contralateral breast cancer, particularly among BRCA1 carriers.31 Our findings showed that the specific altered BRCA gene may be associated with different age at breast cancer onset and type of first DFS event.