Compared with their counterparts, adjusted prevalence of severe DD was higher in adults aged 18 to 49 and 50 to 64 years, Hispanic and non-Hispanic Black adults, adults with a PIR of less than 3.00, adults who reported cost-related insulin underuse, adults with fair/poor self-reported health, and adults with diagnosed depression or anxiety (Table 2). The gene discussed is INS; the disease is major depressive disorder.