Potential sources or triggers of systemic inflammation in patients with MHD typically include the following: biocompatibility of dialysis membranes, accumulation of uremic toxins, inadequate dialysis, infections during dialysis, and chronic diseases (diabetes, cardiovascular disease, etc) Kaizu[24] pointed out that muscle consumption in MHD patients is closely related to inflammatory index, especially the serum interleukin-6 level, and inhibiting these inflammatory responses in patients can improve malnutrition and restore muscle mass. The gene discussed is IL6; the disease is malnutrition.