PTPRC and Menorrhagia: A study has shown that women with menorrhagia have significantly lower concentrations and reduced activity of VEGF, which may impair endometrial repair and early angiogenesis.[37] Basophils and eosinophils also contribute by producing VEGF, supporting angiogenesis and endometrial integrity.[38] In addition, CD45+ granulocytes may help reduce excessive endometrial bleeding by clearing endometrial cellular debris and preventing excessive inflammation.