Heme preparations such as heme arginine and chlormethemoglobin can inhibit ALAS1 activity, thereby reducing ALA and PBG synthesis, which can rapidly alleviate the symptoms.[1,13] The patient’s symptoms significantly improved after treatment with high glucose, arginine heme, corrected electrolyte disorders, and antiepileptic therapy. The gene discussed is ALAS1; the disease is Abnormal blood ion concentration.