Previous proteomic biomarker studies for SCA occurrence are often limited by their focus on commonly used biomarkers like C-reactive protein (CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), and by often relying on samples collected long before or long after the cardiac event occurred [4,5,8]. The gene discussed is NPPB; the disease is autosomal dominant cerebellar ataxia.