Previous proteomic biomarker studies for SCA occurrence are often limited by their focus on commonly used biomarkers like C-reactive protein (CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), and by often relying on samples collected long before or long after the cardiac event occurred [4,5,8]. This evidence concerns the gene CRP and autosomal dominant cerebellar ataxia.