As for CFTR locus, alternative alleles showed increased frequency of 0.32 in CLD vs. 0.09 in controls for rs2283054 (intron 1; P value 1.31x10-9), and 0.30 in CLD vs. 0.05 in controls for rs76622533 (intron 8; P value 2.88x10-16). Here, CFTR is linked to congenital secretory chloride diarrhea 1.