Impaired SLC26A3-mediated chloride-bicarbonate transport in CLD, and the coupled failure of sodium-hydrogen exchanger 3 (NHE3 alias SLC9A3) function, disrupt sodium chloride and fluid reabsorption in the terminal ileum and colon [2]. The gene discussed is SLC9A3; the disease is congenital secretory chloride diarrhea 1.