For the other two SLC26A3 SNPs, located in intron 1, both the rs10953548 alternative allele (P value 1.26x10-6) and the rs1347294065 alternative allele (P value 3.44x10-6) were rare with the frequency of 0.04 in CLD compared with the frequencies of 0.45 and 0.42 in controls, respectively. Here, SLC26A3 is linked to congenital secretory chloride diarrhea 1.