Embelin and SHP099 inhibited the phosphorylation of S6, mTOR, and AKT in A549 and NCI‐H2122 cells, indicating that SHP2 phosphorylation was positively associated with the PI3K/AKT signaling pathway in KRAS‐mutant NSCLC cells (Figure 5E). This evidence concerns the gene AKT1 and non-small cell lung carcinoma.