Consistent with the above results, we found that SHP2 was expressed at a lower level in normal human embryonic kidney HEK293A cells and phosphorylated to a lower degree in RAS wild‐type HEK293A and HeLa cells; the phosphorylation level was significantly elevated in RAS‐mutant cells, especially in the KRAS‐mutant tumor cell lines (Figure 1C). Here, PTPN11 is linked to neoplasm.