To verify the function of SHP2 and XIAP in LUAC, we analyzed The Cancer Genome Atlas (TCGA) database and found that both XIAP and SHP2 were highly correlated with KRAS, and both pharmacological inhibition and genetic knockdown of SHP2 and XIAP resulted in marked cell growth inhibition in KRAS‐mutant NSCLC in a synergistic manner. This evidence concerns the gene XIAP and non-small cell lung carcinoma.