AD and ADRDs all have an abnormal protein aggregation profile that includes (1) extracellular amyloid senile plaque deposition occurring at least 5–10 years before mild cognitive impairments (MCIs) are observed and (2) aggregates of phosphorylated Tau (p-Tau) forming intracellular neurofibrillary tangles (NFTs) (Braak and Braak, 1995; Furman et al., 2017). The gene discussed is MAPT; the disease is Alzheimer disease.