SAR1B and cancer: SAR1B is known to be involved in intracellular leucine sensing, lipid transport, and negative regulation of mTORC1 signaling, a major intracellular pathway central to cancer initiation and progression.45,46 Particularly relevant to these findings is that mTORC1 signaling is activated in high adiposity tissues and actively participates in lipid deposition and adipose tissue expansion.46,47 Thus, it is plausible that a potential decrease in SAR1B expression could play a role in inducing formation of CLS-B, although more mechanistic work is needed.