IL2RB is a cytokine receptor for IL-2 and is associated with the infiltration of immune cells, including high expression in a subset of CD68-positive breast macrophages.48 Several studies have indicated both immunosuppressive and immunostimulatory roles of IL-2 or IL2RB, depending on the context of the tumor microenvironment,49,50 but dysregulated IL2RB expression has been associated with impaired immune response and cancer susceptibility.51 More studies are needed to decipher the exact role of IL2RB in breast carcinogenesis, specifically as it relates to adipose tissue and CLS-B. The gene discussed is CD68; the disease is cancer.