Composed of dead or dying adipocytes surrounded by CD68-positive macrophages, crown-like structures of the breast (CLS-B) are considered as a hallmark of adipose tissue inflammation and have been shown to be associated with obesity, older age, unfavorable metabolic profile, and increased breast cancer risk.21,22,23,24,25 However, the occurrence of CLS-B has not been studied in the context of socioenvironmental factors. The gene discussed is PPIB; the disease is breast cancer.