Mutations in AKT3 and C8orf34 were significantly enriched in EBV-positive cases whereas mutations in FAT3, LRB1B, LRP2, NF1 and TOP2A were predominantly identified in EBV-negative cHL, hinting at a partially distinct molecular pathogenesis (Fig. 2C). The gene discussed is FAT3; the disease is classic Hodgkin lymphoma.