CDDP–BEZ NPs specificallyenhanced cytotoxicity in cancer cells due to the synergy between cisplatinand dactolisib, resulting in augmented DNA damage, activation of mitochondria-dependentapoptosis, and increased inhibition on the PI3K/mTOR signaling axis.The inhibition of tumor migration and metastasis by CDDP–BEZNPs was observed both in vitro and in vivo. The gene discussed is MTOR; the disease is neoplasm.