Moreover, an advanced predictive model combining microbial signatures of Lacticaseibacillus, Haemophilus, and Campylobacter with twist family bHLH transcription factor 1 methylation levels, age, sex, atrophic gastritis, and intestinal metaplasia demonstrated exceptional accuracy in identifying H. pylori‐negative GC patients, with an AUC of 0.994 (Kim et al. 2024). The gene discussed is HNF1A; the disease is gastric cancer.