To explore this hypothesis, we measured insulin resistance by using the triglyceride–glucose (TyG) index, which has been shown to be a reliable clinical surrogate marker of insulin resistance. The TyG index has shown good performance in the estimation of insulin resistance compared with the homeostasis model assessment of insulin resistance (HOMA‐IR) index in individuals with and without diabetes, while it does not require insulin quantification and it is independent of insulin treatment status.29, 30, 31, 32, 33. The gene discussed is INS; the disease is diabetes mellitus.