A number of studies analyzed HERV expression in CRC, focusing especially on the Class I gammaretrovirus‐like HERV‐H group–that is one of the most numerous, counting more than 1000 integrations in the human genome [2, 9]–and on the Class II betaretrovirus‐like HERV‐K (HML2) group, that is, the most recently integrated in humans, with latest acquisitions occurred around 0.2 million of years ago [10, 11]. The gene discussed is CLEC10A; the disease is colorectal carcinoma.